Tumor Necrosis Factor Receptors
作者： T.C. Cheung , C.F. Ware
DOI: 10.1016/B978-0-12-378630-2.00358-3
关键词:
摘要: Tumor necrosis factor receptors (TNFRs) are a family of structurally similar membrane proteins that act as communication pathways activate cell death or induce the expression genes involved in cellular differentiation and survival. These operate many organ systems prominently immune system. TNFRs bind canonical cytokines related to tumor (TNF), but some can also engage members immunoglobulin (Ig) superfamily. The regulate development system initiation inflammatory reactions for effective host defenses against viral bacterial pathogens. A crucial role TNFR immunobiology is evidenced by linkage naturally occurring mutations TNF human disease, well targeting viruses evade blunt responses. Substantial evidence from both diseases experimental has indicated dysregulation TNFRSF signaling promote autoimmune diseases. Inhibitors used treat patients with certain Thus, superfamily constitutes an important molecular target drug intervention.
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