A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

摘要: A major obstacle for successful axon regeneration in the adult central nervous system (CNS) arises from inhibitory molecules CNS myelin, which signal through a common receptor complex on neurons consisting of ligand-binding Nogo-66 (NgR) and two transmembrane coreceptors, p75 LINGO-1. However, expression is only detectable subpopulations mature neurons, raising question how these signals are transduced lacking p75. In this study, we demonstrate that TROY (also known as TAJ), TNF family member selectively expressed system, can form functional with NgR LINGO-1 to mediate cellular responses myelin inhibitors. Also, both overexpressing dominant-negative or presence soluble protein efficiently block neuronal response Our results implicate mediating inhibition, offering new insights into molecular mechanisms failure system.