17β-Estradiol and testosterone in sarcopenia: Role of satellite cells.

作者: Anabela La Colla , Lucía Pronsato , Lorena Milanesi , Andrea Vasconsuelo

DOI: 10.1016/J.ARR.2015.07.011

关键词:

摘要: The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration myocyte via apoptosis might be responsible for perfomance decline. Interestingly, has been associated deficit sex hormones which decrease upon aging. skeletal ability repair regenerate itself would not possible without satellite cells, subpopulation cells remain quiescent throughout life. They activated in response stress, enabling them guide regeneration. Thus, these could key factor overcome sarcopenia. Of importance, 17β-estradiol (E2) testosterone (T) targets. In this review, we summarize potential through regulate activation during regeneration advance its understanding will help development therapeutic agents alleviate treat other related myophaties.

参考文章(193)
Kirsten Avlund, Era Pertti, Kerstin Frändin, Marianne Schroll, Harri Suominen, Taina Rantanen, Muscle strength as a predictor of onset of ADL dependence in people aged 75 years. Aging Clinical and Experimental Research. ,vol. 14, pp. 10- 15 ,(2002)
Giorgio Fanò, Patrizia Mecocci, Jacopo Vecchiet, Silvia Belia, Stefania Fulle, M. Cristina Polidori, Giorgio Felzani, Umberto Senin, Leonardo Vecchiet, M. Flint Beal, Age and sex influence on oxidative damage and functional status in human skeletal muscle. Journal of Muscle Research and Cell Motility. ,vol. 22, pp. 345- 351 ,(2001) , 10.1023/A:1013122805060
A. Thomas, K. Bunyan, P. M. Tiidus, Oestrogen receptor-alpha activation augments post-exercise myoblast proliferation. Acta Physiologica. ,vol. 198, pp. 81- 89 ,(2010) , 10.1111/J.1748-1716.2009.02033.X
Dirk Pette, Robert S. Staron, Mammalian Skeletal Muscle Fiber Type Transitions International Review of Cytology. ,vol. 170, pp. 143- 223 ,(1997) , 10.1016/S0074-7696(08)61622-8
Allan Spradling, Daniela Drummond-Barbosa, Toshie Kai, Stem cells find their niche Nature. ,vol. 414, pp. 98- 104 ,(2001) , 10.1038/35102160
Brian R. MacIntosh, Phillip F. Gardiner, Alan J. McComas, Skeletal Muscle: Form and Function ,(1996)
Dennis R. Campion, The muscle satellite cell: a review. International Review of Cytology-a Survey of Cell Biology. ,vol. 87, pp. 225- 251 ,(1984) , 10.1016/S0074-7696(08)62444-4
G.J. Amelink, P.R. Bär, Exercise-induced muscle protein leakage in the rat. Effects of hormonal manipulation. Journal of the Neurological Sciences. ,vol. 76, pp. 61- 68 ,(1986) , 10.1016/0022-510X(86)90142-5
W. Peter M. BENTEN, MICHELE LIEBERHERR, GüNTER GIESE, CHRISTIAN WREHLKE, OLAF STAMM, CONSTANTIN E. SEKERIS, HORST MOSSMANN, FRANK WUNDERLICH, Functional testosterone receptors in plasma membranes of T cells The FASEB Journal. ,vol. 13, pp. 123- 133 ,(1999) , 10.1096/FASEBJ.13.1.123