作者: Anabela La Colla , Lucía Pronsato , Lorena Milanesi , Andrea Vasconsuelo
DOI: 10.1016/J.ARR.2015.07.011
关键词:
摘要: The loss of muscle mass and strength with aging, referred to as sarcopenia, is a prevalent condition among the elderly. Although molecular mechanisms underlying sarcopenia are unclear, evidence suggests that an age-related acceleration myocyte via apoptosis might be responsible for perfomance decline. Interestingly, has been associated deficit sex hormones which decrease upon aging. skeletal ability repair regenerate itself would not possible without satellite cells, subpopulation cells remain quiescent throughout life. They activated in response stress, enabling them guide regeneration. Thus, these could key factor overcome sarcopenia. Of importance, 17β-estradiol (E2) testosterone (T) targets. In this review, we summarize potential through regulate activation during regeneration advance its understanding will help development therapeutic agents alleviate treat other related myophaties.