Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola.
作者： Bianca E Gama , Guilhermina AL Pereira-Carvalho , Florbela JI Lutucuta Kosi , Natália K Almeida de Oliveira , Filomeno Fortes
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摘要: Plasmodium falciparum malaria remains a leading health problem in Africa and its control is seriously challenged by drug resistance. Although resistance to the sulphadoxine-pyrimethamine (SP) widespread, this combination an important component of programmes as intermittent preventive therapy (IPT) for pregnant women children. In Angola, patterns have been poorly characterized, IPT has employed since 2006. The aim study was assess prevalence key antifolate mediating polymorphisms pfdhfr pfdhps genes P. samples from Angola.
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