CONTROL OF ASPARTATE TRANSCARBAMYLASE ACTIVITY IN TYPE 5 ADENOVIRUS-INFECTED HELA CELLS

摘要: Consigli, Richard A. (University of Pennsylvania, Philadelphia), and Harold S. Ginsberg. Control aspartate transcarbamylase activity in type 5 adenovirus-infected HeLa cells. J. Bacteriol. 87:1027–1033. 1964.—Type adenovirus infection induces increased (ATCase) during the period magnified nucleic acid biosynthesis. Increased can be prevented by addition pyrimidines to culture medium. ATCase cells is regulated feedback inhibition, purified enzyme inhibited vitro cytidine triphosphate (CTP). The from infected has a pH optimum, maximal velocity, Km for distinctly different control However, heating uninfected converts so that its characteristics are identical with Conversely, CTP changes they same as those evidence presented suggests biosynthesis initiates release inhibition increases reducing concentration purines acid-soluble pool.