Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism

摘要: Viruses rely on the metabolic network of host cell to provide energy and macromolecular precursors fuel viral replication. Here we used mass spectrometry examine impact two related herpesviruses, human cytomegalovirus (HCMV) herpes simplex virus type-1 (HSV-1), metabolism fibroblast epithelial cells. Each triggered strong changes that were conserved across different types. The effects viruses were, however, largely distinct. HCMV but not HSV-1 increased glycolytic flux. profoundly TCA compound levels flow carbon units required for cycle turning fatty acid synthesis. anapleurotic influx through pyruvate carboxylase, feeding pyrimidine biosynthesis. Thus, these herpesviruses drive diverse cells execute distinct, virus-specific programs. Current drugs target nucleotide treatment both viruses. Although our results confirm this is a robust HSV-1, therapeutic interventions at other points in might prove more effective HCMV.