ECD carboxy-terminal deletion FGFR4 fusion proteins and methods of producing them
作者： Diane Hollenbaugh , Minmin Qin , Ernestine Lee , Ali Sadra , Elizabeth Bosch
DOI:
关键词:
摘要: The invention provides FGFR fusion proteins, methods of making them, and using them to treat proliferative disorders, including cancers disorders angiogenesis. molecules can be made in CHO cells may comprise deletion mutations the extracellular domains FGFRs which improve their stability. These proteins inhibit growth viability cancer vitro vivo. combination relatively high affinity these receptors for ligand FGFs demonstrated ability decoy tumor is an indication clinical value compositions provided herein.
lens.org 参考文章(77)
David Cappellen, Jean-Paul Thiery, François Radvanyi, Dominique Chopin, David Ricol, Means for detecting and treating pathologies linked to fgfr3 ,(2000)
A Hanneken, A Baird, Soluble forms of the high-affinity fibroblast growth factor receptor in human vitreous fluid. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 1192- 1196 ,(1995)
Richard Spaete, Method of producing secreted CMV glycoprotein H ,(1992)
Karin Jooss, Melissa Gonzalez-Edick, Satya Yendluri, Minh Nguyen, Gaung-Huan Tu, Thomas Harding, Role of VEGF, PDGF and FGF in glioblastoma progression as determined by soluble decoy receptor expression in preclinical models Cancer Research. ,vol. 65, pp. 712- 713 ,(2005)
Avner Yayon, Zvi Nevo, Fgfr3 as a marker for mesenchymal skeletal progenitor cells ,(1996)
S R Coughlin, P J Barr, L S Cousens, L J Fretto, L T Williams, Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. Journal of Biological Chemistry. ,vol. 263, pp. 988- 993 ,(1988) , 10.1016/S0021-9258(19)35450-X
Thomas Harding, Minh Nguyen, Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors ,(2006)
Marcus D. Ballinger, Venkatakrishna Shyamala, Louise D. Forrest, Maja Deuter-Reinhard, Laura V. Doyle, Jian-xin Wang, Lootsee Panganiban-Lustan, Jennifer R. Stratton, Gerald Apell, Jill A. Winter, Michael V. Doyle, Steven Rosenberg, W. Michael Kavanaugh, Semirational design of a potent, artificial agonist of fibroblast growth factor receptors Nature Biotechnology. ,vol. 17, pp. 1199- 1204 ,(1999) , 10.1038/70746
M. Roghani, A. Mansukhani, P. Dell'Era, P. Bellosta, C. Basilico, D.B. Rifkin, D. Moscatelli, Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding. Journal of Biological Chemistry. ,vol. 269, pp. 3976- 3984 ,(1994) , 10.1016/S0021-9258(17)41730-3
P.L. Smith, T.P. Skelton, D Fiete, S.M. Dharmesh, M.C. Beranek, L MacPhail, G J Broze, J.U. Baenziger, The asparagine-linked oligosaccharides on tissue factor pathway inhibitor terminate with SO4-4GalNAc beta 1, 4GlcNAc beta 1,2 Mana alpha. Journal of Biological Chemistry. ,vol. 267, pp. 19140- 19146 ,(1992) , 10.1016/S0021-9258(18)41753-X