Aberrantly decreased levels of NKG2D expression in children with kawasaki disease.
作者： X. Ge , C.-R. Li , J. Yang , G.-B. Wang
DOI: 10.1111/SJI.12022
关键词:
摘要: This study is designed to investigate the changes of NKG2D expression on CD8(+) T cells and CD3(-) CD56(+) NK in Kawasaki disease (KD). NKG2D/NKG2A lymphocytes, ligands such as major histocompatibility complex I chain-related molecules A(MICA) UL-16-binding proteins (ULBP-1) CD14(+) mononuclear (MC) were analysed by flow cytometry patients with KD. Real-time polymerase chain reaction (PCR) was used evaluate mRNA levels interleukin (IL)-1β, IL-6 tumour necrosis factor (TNF)-α cells. Plasma cytokine [IL-7, IL-12, IL-15, interferon (IFN)-γ transforming growth (TGF)-β] concentrations measured ELISA. The acute phase KD significantly lower than those normal controls (P < 0.05), coronary artery lesion (KD-CAL(+) ) KD-CAL(-) . There an upregulated tendency after treatment IVIG. We found higher proinflammatory cytokines from MC, IL-1β, TNF-α compared healthy (P < 0.05). IL-7 IL-15 decreased (P < 0.05) some extent elevated therapy IVIG while antagonistic like IFN-γ increased reduced These results suggest that aberrantly might be one factors led disturbed immunological function Cytokines milieu could important causing NKG2D.
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