The influences of Ih on temporal summation in hippocampal CA1 pyramidal neurons: a modeling study.

摘要: Recent experimental and theoretical studies have found that active dendritic ionic currents can compensate for the effects of electrotonic attenuation. In particular, temporal summation, percentage increase in peak somatic voltage responses invoked by a synaptic input train, is independent location hippocampal CA1 pyramidal neurons under normal conditions. This independence, known as normalization destroyed when hyperpolarization-activated current, I h, blocked [Magee JC (1999a), Nature Neurosci. 2: 508–514]. Using compartmental model derived from morphological recordings neurons, we examined hypothesis I h was primarily responsible summation. We concluded this incomplete. With included persistent Na+ current (I NaP), transient A-type K+ (I A), however, observed summation across wide range frequencies, keeping with observations.