Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents.

摘要: We have previously shown that mice lateral superior olive (LSO) neurons exhibit a large hyperpolarization-activated current (I(h) ), and cyclic-nucleotide-gated type 1 channels are present in both the soma dendrites of these cells. Here we show dendritic I(h) LSO modulates integration multiple synaptic inputs. tested neuron's ability to integrate inputs by evoking excitatory post-synaptic potentials (EPSPs) conjunction with brief depolarizing pulses (to simulate second input) at different time delays. compared native (control) without (blocked ZD7288) only peri-somatically (ZD7288+ computer-simulated using dynamic clamp). had wider window for firing response short separations. Simulated somatic (dynamic clamp) could not reverse this effect. Blocking also increased summation EPSPs elicited proximal distal regions, dramatically altered inhibitory potentials. The addition simulated peri-somatic abolish ZD7288-induced increase responsiveness widely separated Using compartmental model, can reduce EPSP locally decreasing input resistance. Our results suggest significant role neurons, where activation/deactivation alter