The vascular basement membrane in the healthy and pathological brain

摘要: The vascular basement membrane contributes to the integrity of blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). BCECs receive support from pericytes embedded in and astrocyte endfeet. forms a three-dimensional protein network predominantly composed laminin, collagen IV, nidogen, heparan sulfate proteoglycans that mutually interactions between BCECs, pericytes, astrocytes. Major changes molecular composition are observed acute chronic neuropathological settings. In present review, we cover significance healthy pathological brain. stroke, loss BBB accompanied upregulation proteolytic enzymes degradation proteins. There yet no causal relationship expression or activity matrix proteases ...