Growth in children after bone marrow transplantation for acute leukemia.

摘要: We evaluated the growth of children with acute leukemia who received a bone marrow transplant (BMT) after preparation hyperfractionated total body irradiation (TBI). Seventy-two patients (27 female and 45 male patients) lymphoblastic (ALL; n = 39) or myelogenous (AML; 33) were less than 14 years age at BMT studied. Before all had multiagent chemotherapy 31 cranial (RT). Preparation for included (1,375 cGy [n 37] 1,500 35]). Heights, expressed as standard deviation scores (SDS), studied up to 4 post-BMT. The estimated height SDS entire group time was -0.28 +/- 0.05 decreased -1.11 0.22 post-BMT (P < .0001). Using curve model compare covariate groups over period study, we found that loss in most significant those RT before .005). treated went from -0.52 0.20 transplantation -1.83 0.23 later. In contrast, did not receive showed smaller decrease 4-year observation period, ie, -0.11 decreasing -0.73 0.21. Similarly, diagnosis ALL greater AML .033). Fifteen 18 tested be hormone (GH) deficient; 9 GH an improvement velocity conclude (1) have subsequently undergo BMT, primarily ALL, are high risk failure deficiency, (2) fractionation TBI may relative sparing effect on growth.