Targeting inflammation: multiple innovative ways to reduce prostaglandin E2

摘要: The PGE2 pathway is important in inflammation-driven diseases and specific targeting of the inducible mPGES-1 warranted due to cardiovascular problems associated with long-term use COX-2 inhibitors. This review focuses on patents issued methods measuring activity, drugs other modulators free extracellular concentration. Perspectives conclusions regarding status these are also presented. Importantly, no selective inhibitors have been identified and, despite high number published patents, none yet made it clinical trials.