Modular synthesis of triaroylbenzene-derived crownophanes

摘要: Abstract An isomeric series of homologous crownophanes (i.e., macrocycles possessing structural features crown ethers and cyclophanes) has been prepared via a concise modular synthetic route. Macrocyclization is achieved in reasonable yield during the course an enaminone-triggered benzannulation with bis(aryl ethynyl ketone) reaction partners. The examined were active alkali cation binding agents gas phase, but failed to exhibit ionophoric properties solution. On basis X-ray crystallographic analysis, it concluded that cyclophane framework these too large rigid allow efficient interaction cations examined.