Sole trisomy 6 an uncommon finding in pediatric acute myeloid leukemia, probably associated to bad prognosis
作者： Sinhue Alejandro Brukman-Jimenez , Lucina Bobadilla-Morales , Jorge Román Corona-Rivera , Pablo Alejandro Chávez-Panduro , Citlalli Ortega-de-la-Torre
DOI: 10.1186/S13039-020-00509-Y
关键词:
摘要: Acute leukemias represent the main malignancies occurring among children under age of 15 years. Around 17% corresponds to acute myeloid leukemia (AML). The cytogenetic analysis bone marrow complements diagnosis hematological malignancies, therefore finding chromosomal aberrations provides a more reliable prognosis disease. Among aberrations, sole trisomy is frequent in malignant neoplasias, but few cases related AML have been reported. We report 6 pediatric patient diagnosed as M4 and poor progression. carried out literature review patients with compared their evolution against normal karyotype. This first case this finding. Sole infrequently reported scarce cases. Based on overall survival analysis, we suggest that could be associated prognosis, both, adult well AML.
biomedcentral.com
scilit.net
springer.com 参考文章(31)
Khalil M. Charafeddine, Hassan A. Hatoum, Zaher K. Otrock, Rami A. Mahfouz, Ziad M. Salem, Ali I. Shamseddine, Ali T. Taher, Nagi S. El-Saghir, Ali Bazarbachi, Long-term outcome of adult acute lymphoblastic leukemia in Lebanon Hematology/Oncology and Stem Cell Therapy. ,vol. 2, pp. 333- 339 ,(2009) , 10.1016/S1658-3876(09)50021-0
Gitte B Kerndrup, Eigil Kjeldsen, Acute leukemia cytogenetics : an evaluation of combining G-band karyotyping with multi-color spectral karyotyping Cancer Genetics and Cytogenetics. ,vol. 124, pp. 7- 11 ,(2001) , 10.1016/S0165-4608(99)00223-X
WF Benedict, M Lange, J Greene, A Derencsenyi, OS Alfi, Correlation between prognosis and bone marrow chromosomal patterns in children with acute nonlymphocytic leukemia: similarities and differences compared to adults. Blood. ,vol. 54, pp. 818- 823 ,(1979) , 10.1182/BLOOD.V54.4.818.818
J. R. Testa, S. Misawa, N. Oguma, K. Van Sloten, P. H. Wiernik, Chromosomal alterations in acute leukemia patients studied with improved culture methods. Cancer Research. ,vol. 45, pp. 430- 434 ,(1985)
L.C. Chan, Y.L. Kwong, H.W. Liu, T.K. Chan, D. Todd, L.M. Ching, Cytogenetic analysis of hematologic malignancies in Hong Kong: A study of 98 cases Cancer Genetics and Cytogenetics. ,vol. 62, pp. 154- 159 ,(1992) , 10.1016/0165-4608(92)90255-7
S Misawa, S Horiike, K Kashima, H Kaneko, T Iwai, M Nakao, S Yokota, T Fujimoto, Y Sonoda, Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. ,vol. 10, pp. 1911- 1918 ,(1996)
Elias Campo, N Lee Harris, Elaine S Jaffe, Stefano A Pileri, Harald Stein, Jurgen Thiele, James W Vardiman, None, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues ,(2017)
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Shinae Yu, Min-Jung Kwon, Seung-Tae Lee, Hee-Yeon Woo, Hyosoon Park, Sun-Hee Kim, Analysis of Acute Myeloid Leukemia in Korean Patients with Sole Trisomy 6 Korean Journal of Laboratory Medicine. ,vol. 34, pp. 402- 404 ,(2014) , 10.3343/ALM.2014.34.5.402
Sverre Heim, Felix Mitelman, Numerical chromosome aberrations in human neoplasia Cancer Genetics and Cytogenetics. ,vol. 22, pp. 99- 108 ,(1986) , 10.1016/0165-4608(86)90169-X