Sexual dimorphism in brain transcriptomes of Amami spiny rats ( Tokudaia osimensis ): a rodent species where males lack the Y chromosome
作者： Madison T. Ortega , Nathan J. Bivens , Takamichi Jogahara , Asato Kuroiwa , Scott A. Givan
DOI: 10.1186/S12864-019-5426-6
关键词:
摘要: Brain sexual differentiation is sculpted by precise coordination of steroid hormones during development. Programming several brain regions in males depends upon aromatase conversion testosterone to estrogen. However, it not clear the direct contribution that Y chromosome associated genes, especially sex-determining region (Sry), might exert on therian mammals. Two species spiny rats: Amami rat (Tokudaia osimensis) and Tokunoshima (T. tokunoshimensis) lack a chromosome/Sry, these individuals possess an XO system both sexes. Both Tokudaia are highly endangered. To assess neural transcriptome profile male female rats, RNA was isolated from samples adult rats had died accidentally used for RNAseq analyses. analyses confirmed genes individual transcripts were differentially expressed between females. In males, seminal vesicle secretory protein 5 (Svs5) cytochrome P450 1B1 (Cyp1b1) significantly elevated compared females, whereas serine (or cysteine) peptidase inhibitor, clade A, member 3 N (Serpina3n) upregulated Many included those encoding zinc finger proteins, e.g. X-linked (Zfx). This method successfully identified showed expression differences rat. The functional significance findings, differential this unusual rodent remains be determined.
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sci-hub.se 参考文章(109)
Scott A. Givan, Christopher A. Bottoms, William G. Spollen, Computational analysis of RNA-seq. Methods of Molecular Biology. ,vol. 883, pp. 201- 219 ,(2012) , 10.1007/978-1-61779-839-9_16
V. Cunliffe, P. Koopman, A. McLaren, J. Trowsdale, A mouse zinc finger gene which is transiently expressed during spermatogenesis. The EMBO Journal. ,vol. 9, pp. 197- 205 ,(1990) , 10.1002/J.1460-2075.1990.TB08096.X
Jennifer A. Marshall Graves, Evolution of the testis-determining gene--the rise and fall of SRY. Novartis Foundation symposium. ,vol. 244, pp. 86- 101 ,(2002) , 10.1002/0470868732.CH9
Sara Naurin, Bengt Hansson, Dennis Hasselquist, Yong-Hwan Kim, Staffan Bensch, The sex-biased brain: sexual dimorphism in gene expression in two species of songbirds BMC Genomics. ,vol. 12, pp. 37- 37 ,(2011) , 10.1186/1471-2164-12-37
A MCPHIELALMANSINGH, L TEJADA, J WEAVER, E RISSMAN, Sex chromosome complement affects social interactions in mice. Hormones and Behavior. ,vol. 54, pp. 565- 570 ,(2008) , 10.1016/J.YHBEH.2008.05.016
Xuqi Chen, Rebecca McClusky, Jenny Chen, Simon W. Beaven, Peter Tontonoz, Arthur P. Arnold, Karen Reue, The number of x chromosomes causes sex differences in adiposity in mice. PLOS Genetics. ,vol. 8, pp. 1- 14 ,(2012) , 10.1371/JOURNAL.PGEN.1002709
Diego Cortez, Ray Marin, Deborah Toledo-Flores, Laure Froidevaux, Angélica Liechti, Paul D. Waters, Frank Grützner, Henrik Kaessmann, Origins and functional evolution of Y chromosomes across mammals Nature. ,vol. 508, pp. 488- 493 ,(2014) , 10.1038/NATURE13151
M. Świtoński, H. Jackowiak, S. Godynicki, J. Klukowska, K. Borsiak, K. Urbaniak, Familial occurrence of pig intersexes (38,XX; SRY-negative) on a commercial fattening farm. Animal Reproduction Science. ,vol. 69, pp. 117- 124 ,(2002) , 10.1016/S0378-4320(01)00168-3
James T. Watson, Elizabeth Adkins-Regan, Testosterone implanted in the preoptic area of male Japanese quail must be aromatized to activate copulation Hormones and Behavior. ,vol. 23, pp. 432- 447 ,(1989) , 10.1016/0018-506X(89)90055-X
Dika A Kuljis, Dawn H Loh, Danny Truong, Andrew M Vosko, Margaret L Ong, Rebecca McClusky, Arthur P Arnold, Christopher S Colwell, None, Gonadal- and Sex-Chromosome-Dependent Sex Differences in the Circadian System Endocrinology. ,vol. 154, pp. 1501- 1512 ,(2013) , 10.1210/EN.2012-1921