Long-term follow-up of hypopituitary patients treated with human growth hormone.

摘要: Thirty-six former human growth hormone (hGH) recipients underwent comprehensive physical, endocrine and lipoprotein evaluations as adults. Treatment was associated with a decrease in height standard deviation score (SDS) males from 4.0 pretreatment to 2.1 adults, females 4.2 2.5. Males showed better response treatment than did females. Plasma somatomedin-C levels were subnormal 30 patients, but higher isolated growth-hormone-deficient patients others. Three men 1 woman evidence suggesting disturbance pulsatile gonadotropin release despite the previous documentation of normal serum levels. Hypertriglyceridemia not observed, women's plasma cholesterol unremarkable. Men, however, higher-than-expected total cholesterol, LDL-cholesterol, HDL-cholesterol concentrations. The last finding may explain lack increased cardiovascular morbidity this group.