Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases

摘要: Introduction: GPR119 is a recently deorphanised G-protein coupled receptor which has been suggested to be important in mediating systemic metabolic homeostasis. Research date primarily focused on the ability of promote euglycaemia and thus as therapeutic target for treatment type 2 diabetes mellitus (T2DM). Indeed, previous studies have shown that promotes glucose-stimulated insulin secretion, pancreatic β-cell function glucagon-like peptide-1 release, all provide valid mechanisms through may improve glucose Areas covered: In current review, authors brief overview known functions then discuss novel potential regulate skeletal cardiac muscle how this translate improvements or impairments health. Expert opinion: largely purported being anti-diabetic rapidly progressed clinical trials, mainly ...