Vitamin D and the Parathyroids
作者： Justin Silver , Tally Naveh-Many
DOI: 10.1007/978-1-60327-303-9_10
关键词:
摘要: The administration of 1,25-dihydroxyvitamin D3 [1,25(OH)2D] results in a dramatic decrease PTH mRNA levels rats with no change serum calcium levels. 1,25(OH)2D or its analogs has become an important part the management secondary hyperparathyroidism due to chronic renal failure. acts gene transcription. Two mechanisms may play role transrepression. First, VDRE been described promoter, which mediates transrepression transfected cells. In addition, alternative E-box-like motif identified as another class nVDRE human 1α-hydroxylase promoter. Negative regulation hPTH by liganded receptor (VDR) is mediated VDR-interacting repressor, VDIR, directly binding E-box-type at Post-transcriptional experimental kidney failure and after changes dietary phosphorus are pertinent understanding expression. These involve trans-acting factors defined cis-acting instability element 3ʹ-untranslated region. bone-derived hormone, fibroblast growth factor (FGF) 23 increased phosphate on cause phosphaturia synthesis. FGF23 parathyroid
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