In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene
作者： Alexander Kel , Maurice Scheer , Hubert Mayer
关键词: Binding site 、 Hormone 、 Transcription factor 、 Computational biology 、 DNA binding site 、 Organism 、 Biology 、 Gene 、 In silico 、 Regulatory sequence 、 Bioinformatics
摘要: In silico analysis of the regulatory sequences provides a very efficient means for investigating regulation eukaryotic genes. We have applied number computer tools searching potential TF binding sites and their organisation in PTH gene. found many different transcription factors that may contribute to With this approach full elements gene can be described results bring us principally new level understanding how genes are regulated during development functioning organism dis-regulated is cases diseases.
springer.com
springerlink.com参考文章(33)
Alexander E. Kel, Ellen Gößling, Olga V. Kel-Margoulis, Edgar Wingender, MATCH TM - a tool for searching transcription factor binding sites in DNA sequences. Application for the analysis of human chromosomes. german conference on bioinformatics. pp. 158- 161 ,(2001)
T. Okazaki, J.D. Zajac, T. Igarashi, E. Ogata, H.M. Kronenberg, Negative regulatory elements in the human parathyroid hormone gene. Journal of Biological Chemistry. ,vol. 266, pp. 21903- 21910 ,(1991) , 10.1016/S0021-9258(18)54722-0
T Okazaki, U Chung, T Nishishita, S Ebisu, S Usuda, S Mishiro, S Xanthoudakis, T Igarashi, E Ogata, A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. Journal of Biological Chemistry. ,vol. 269, pp. 27855- 27862 ,(1994) , 10.1016/S0021-9258(18)46865-2
Ross C. Hardison, John Oeltjen, Webb Miller, Long Human–Mouse Sequence Alignments Reveal Novel Regulatory Elements: A Reason to Sequence the Mouse Genome Genome Research. ,vol. 7, pp. 959- 966 ,(1997) , 10.1101/GR.7.10.959
R J Rickles, A L Darrow, S Strickland, Differentiation-responsive elements in the 5' region of the mouse tissue plasminogen activator gene confer two-stage regulation by retinoic acid and cyclic AMP in teratocarcinoma cells. Molecular and Cellular Biology. ,vol. 9, pp. 1691- 1704 ,(1989) , 10.1128/MCB.9.4.1691
S. Xanthoudakis, G. Miao, F. Wang, Y.C. Pan, T. Curran, Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme. The EMBO Journal. ,vol. 11, pp. 3323- 3335 ,(1992) , 10.1002/J.1460-2075.1992.TB05411.X
S. M. Farrow, N. S. Hawa, R. Karmali, M. Hewison, J. C. Walters, J. L. H. O'Riordan, Binding of the receptor for 1,25-dihydroxyvitamin D3 to the 5'-flanking region of the bovine parathyroid hormone gene. Journal of Endocrinology. ,vol. 126, pp. 355- 359 ,(1990) , 10.1677/JOE.0.1260355
Ella W. Englander, Samuel H. Wilson, Protein binding elements in the human β-polymerase promoter Nucleic Acids Research. ,vol. 18, pp. 919- 928 ,(1990) , 10.1093/NAR/18.4.919
A Miric, M A Levine, Analysis of the preproPTH gene by denaturing gradient gel electrophoresis in familial isolated hypoparathyroidism. The Journal of Clinical Endocrinology and Metabolism. ,vol. 74, pp. 509- 516 ,(1992) , 10.1210/JCEM.74.3.1740484
Hisham M. Darwish, Hector F. DeLuca, Identification of a transcription factor that binds to the promoter region of the human parathyroid hormone gene. Archives of Biochemistry and Biophysics. ,vol. 365, pp. 123- 130 ,(1999) , 10.1006/ABBI.1999.1160