The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.

作者: Keiki Kumano , Mineo Kurokawa

DOI: 10.1002/JCP.21953

关键词:

摘要: … This review focuses on the role of Runx1 and Evi-1 in the formation and proliferative expansion versus quiescence of embryonic and adult HSCs using mainly our previous works. …

参考文章(52)
Yoichi Imai, Mineo Kurokawa, Koji Izutsu, Akira Hangaishi, Kengo Takeuchi, Kazuhiro Maki, Seishi Ogawa, Shigeru Chiba, Kinuko Mitani, Hisamaru Hirai, Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis Blood. ,vol. 96, pp. 3154- 3160 ,(2000) , 10.1182/BLOOD.V96.9.3154
Woo-Joo Song, Melanie G. Sullivan, Robert D. Legare, Sarah Hutchings, Xiaolian Tan, Dubravka Kufrin, Janina Ratajczak, Isabel C. Resende, Catherine Haworth, Randy Hock, Mignon Loh, Carolyn Felix, Denis-Claude Roy, Lambert Busque, David Kurnit, Cheryl Willman, Alan M. Gewirtz, Nancy A. Speck, John H. Bushweller, Frederick P. Li, Katheleen Gardiner, Mortimer Poncz, John M. Maris, D. Gary Gilliland, Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia Nature Genetics. ,vol. 23, pp. 166- 175 ,(1999) , 10.1038/13793
Motoshi Ichikawa, Susumu Goyama, Takashi Asai, Masahito Kawazu, Masahiro Nakagawa, Masataka Takeshita, Shigeru Chiba, Seishi Ogawa, Mineo Kurokawa, AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. Journal of Immunology. ,vol. 180, pp. 4402- 4408 ,(2008) , 10.4049/JIMMUNOL.180.7.4402
R Delwel, T Funabiki, B L Kreider, K Morishita, J N Ihle, Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA. Molecular and Cellular Biology. ,vol. 13, pp. 4291- 4300 ,(1993) , 10.1128/MCB.13.7.4291
A S Perkins, R Fishel, N A Jenkins, N G Copeland, Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein Molecular and Cellular Biology. ,vol. 11, pp. 2665- 2674 ,(1991) , 10.1128/MCB.11.5.2665
T. S. Fenske, G. Pengue, V. Mathews, P. T. Hanson, S. E. Hamm, N. Riaz, T. A. Graubert, Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 15184- 15189 ,(2004) , 10.1073/PNAS.0400751101
Olga Kustikova, Boris Fehse, Ute Modlich, Min Yang, Jochen Düllmann, Kenji Kamino, Nils von Neuhoff, Brigitte Schlegelberger, Zhixiong Li, Christopher Baum, Clonal Dominance of Hematopoietic Stem Cells Triggered by Retroviral Gene Marking Science. ,vol. 308, pp. 1171- 1174 ,(2005) , 10.1126/SCIENCE.1105063
Masahiro Nakagawa, Motoshi Ichikawa, Keiki Kumano, Susumu Goyama, Masahito Kawazu, Takashi Asai, Seishi Ogawa, Mineo Kurokawa, Shigeru Chiba, AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis. Blood. ,vol. 108, pp. 3329- 3334 ,(2006) , 10.1182/BLOOD-2006-04-019570
Igor M. Samokhvalov, Natalia I. Samokhvalova, Shin-ichi Nishikawa, Cell tracing shows the contribution of the yolk sac to adult haematopoiesis Nature. ,vol. 446, pp. 1056- 1061 ,(2007) , 10.1038/NATURE05725
Martin Gering, Roger Patient, Hedgehog Signaling Is Required for Adult Blood Stem Cell Formation in Zebrafish Embryos Developmental Cell. ,vol. 8, pp. 389- 400 ,(2005) , 10.1016/J.DEVCEL.2005.01.010