Capacitive deionization on-chip as a method for microfluidic sample preparation.

摘要: Desalination as a sample preparation step is essential for noise reduction and reproducibility of mass spectrometry measurements. A specific example the analysis proteins medical research clinical applications. Salts buffers that are present in samples need to be removed before improve signal-to-noise ratio. Capacitive deionization an electrostatic desalination (CDI) technique which uses two porous electrodes facing each other remove ions from solution. Upon application potential 0.5 V migrate stored electrical double layer. In this article we demonstrate CDI on chip, desalinate solution by removal 23% Na+ Cl− ions, while concentration larger molecule (FITC-dextran) remains unchanged. For first time impedance spectroscopy introduced monitor salt situ real-time between electrodes.