Persistence of echovirus 6 in cloned human cells.

摘要: Establishment of a persistent infection by echovirus 6 in cloned human WISH cells (PI) was demonstrated. The were maintained for 3.0 years (over 125 passages) and released virus continuously without cellular destruction. Neither temperature-sensitive mutants nor interferon appears to play role either establishment or maintenance viral persistence. majority the produced is defective (2 X 10(6) particles per PFU) differs from standard its polypeptide profile inability attach parental cells.