Diabetes mellitus due to viruses - some recent developments

摘要: Many different viruses belonging to several genera have the potential damage beta cells. The mechanisms they employ are varied, and infection may result in either a direct destruction of islets rapid insulin deficiency, or more gradual loss functioning with onset diabetes many years later. Several case histories involving extensive cytolysis cells can be directly linked viral infection, whilst an example occurring after is found individuals who had congenital rubella virus. Here, virus induces autoimmune reaction against Autoimmune phenomena also been observed following infections other than rubella, thus activation leading beta-cell relatively frequent occurrence. Recent evidence shows that picornaviruses not exclusively lytic, induce subtle, long-term changes cells, which important aetiology diabetes. exact involved known, but it clear inhibit synthesis expression proteins such as interferons, HLA antigens. Strain differences since all variants tropic for laboratories process identifying genetic determinants tropism diabetogenicity, especially amongst Coxsackie B (CB) group. sequence one diabetogenic CB4 strain has determined. It therefore there diabetes, involvement pathogenesis established some instances. Further research work at both fundamental epidemiological level now urgently needed define nature interaction cell.