A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation.

作者: Olivier Pertz , Damir Bozic , Alexander W Koch , Charlotte Fauser , Andrea Brancaccio

DOI: 10.1093/EMBOJ/18.7.1738

关键词:

摘要: A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details … A new crystal structure of ECAD12 was solved in which, in contrast to the earlier structures …

参考文章(42)
Hiroshi Takeda, Yutaka Shimoyama, Akira Nagafuchi, Setsuo Hirohashi, E-cadherin functions as a cis -dimer at the cell–cell adhesive interface in vivo Nature Structural & Molecular Biology. ,vol. 6, pp. 310- 312 ,(1999) , 10.1038/7542
G Sarkar, S S Sommer, The "megaprimer" method of site-directed mutagenesis. BioTechniques. ,vol. 8, pp. 404- 407 ,(1990)
A. Tomschy, C. Fauser, R. Landwehr, J. Engel, HOMOPHILIC ADHESION OF E-CADHERIN OCCURS BY A CO-OPERATIVE TWO-STEP INTERACTION OF N-TERMINAL DOMAINS The EMBO Journal. ,vol. 15, pp. 3507- 3514 ,(1996) , 10.1002/J.1460-2075.1996.TB00719.X
Alpha S. Yap, Carien M. Niessen, Barry M. Gumbiner, The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn Journal of Cell Biology. ,vol. 141, pp. 779- 789 ,(1998) , 10.1083/JCB.141.3.779
G Mbalaviele, H Chen, B F Boyce, G R Mundy, T Yoneda, The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. Journal of Clinical Investigation. ,vol. 95, pp. 2757- 2765 ,(1995) , 10.1172/JCI117979
Akinao Nose, Katsumi Tsuji, Masatoshi Takeichi, Localization of specificity determining sites in cadherin cell adhesion molecules Cell. ,vol. 61, pp. 147- 155 ,(1990) , 10.1016/0092-8674(90)90222-Z
Orest W. Blaschuk, Robert Sullivan, S. David, Yannick Pouliot, Identification of a cadherin cell adhesion recognition sequence. Developmental Biology. ,vol. 139, pp. 227- 229 ,(1990) , 10.1016/0012-1606(90)90290-Y
M Takeichi, Cadherin cell adhesion receptors as a morphogenetic regulator Science. ,vol. 251, pp. 1451- 1455 ,(1991) , 10.1126/SCIENCE.2006419