Calcium Binding to Extracellular Matrix Proteins, Functional and Pathological Effects

摘要: Calcium concentrations in the extracellular space are 4 to 5 orders of magnitude larger than inside cells. These highly controlled by a unique receptor system (Brown et al., 1995); Ward and Ricardi, this book; Brown book). Free calcium concentration serum has been determined be 1.2 mM, however, spatial time-dependent fluctuations have detected (for review, see Maurer 1996). Many different proteins bind ions variety calcium-binding motifs identified these proteins, e.g. EF-hand motif, which is common cytosolic (Maurer bound may serve various functions, but primarily stabilize protein structure explains tight binding (micromolar or smaller K D values). In addition, sites for weakly sense variations levels involved regulation 1996); (Koch 1997). This chapter will focus on relevant findings concerning functional pathological effects two matrix (fibrillin-1 COMP) cell adhesion E-cadherin. Possible molecular mechanisms discussed as well.