Interference of oral phenytoin absorption by continuous nasogastric feedings

摘要: Inhibition of phenytoin absorption by continuous nasogastric tube feeding was studied in 20 neurosurgery patients and 5 normal subjects. Ten receiving suspension 300 mg per day coadministered with feedings had a mean serum concentration 2.59 micrograms milliliter. When the were discontinued, average rose to 10.22 milliliter 7 days. In 10 other stabilized on day, decreased from 9.80 microgram 2.72 days when started. Five subjects received single oral dose alone while drinking preparation orally at rate 100 ml hour; levels an 71.6% taken concurrently.