Medications in older patients.

作者: M Hobson

DOI:

关键词: Intensive care medicineDiseaseMedicinePharmacodynamicsAnticholinergicAnesthesiaPharmacotherapyDrugEfficacyPatient educationPharmacokinetics

摘要: Adverse drug reactions are common in persons aged 65 and older associated with increased morbidity mortality. A heightened susceptibility to adverse is due a number of factors, including an incidence disease, multiple use, altered pharmacokinetic pharmacodynamic properties many drugs. The risk interactions increases the medications taken. can be prevented through prudent prescribing practices, patient education, adequate monitoring efficacy side effects. Several types particular concern, antihypertensive agents, drugs anticholinergic effects, psychoactive medications, nonsteroidal anti-inflammatory Some drugs, such as histamine H2-receptor antagonists, relatively safe but overprescribed. Data regarding risks these problem presented, recommendations for effective treatment alternatives.

参考文章(34)
L Jarvik, R Gerner, J Steuer, W Estabrook, Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study. The Journal of Clinical Psychiatry. ,vol. 41, pp. 216- 220 ,(1980)
Feely John, Coakley Davis, Altered Pharmacodynamics in the Elderly Clinics in Geriatric Medicine. ,vol. 6, pp. 269- 283 ,(1990) , 10.1016/S0749-0690(18)30616-5
Satel Sl, Nelson Jc, Stimulants in the treatment of depression: a critical overview. The Journal of Clinical Psychiatry. ,vol. 50, pp. 241- 249 ,(1989)
Geoffrey J. Yuen, Altered Pharmacokinetics in the Elderly Clinics in Geriatric Medicine. ,vol. 6, pp. 257- 267 ,(1990) , 10.1016/S0749-0690(18)30615-3
Marcus M. Reidenberg, Micha Levy, Howard Warner, Claude B. Coutinho, Morton A. Schwartz, George Yu, Joyce Cheripko, Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clinical Pharmacology & Therapeutics. ,vol. 23, pp. 371- 374 ,(1978) , 10.1002/CPT1978234371
Franklin E. May, Ronald B. Stewart, Leighton E. Cluff, Drug interactions and multiple drug administration Clinical Pharmacology & Therapeutics. ,vol. 22, pp. 322- 328 ,(1977) , 10.1002/CPT1977223322
Fran E. Kaiser, John E. Morley, Cholesterol can be lowered in older persons. Should we care Journal of the American Geriatrics Society. ,vol. 38, pp. 84- 85 ,(1990) , 10.1111/J.1532-5415.1990.TB01604.X
Donald W. Cockcroft, Henry Gault, Prediction of Creatinine Clearance from Serum Creatinine Nephron. ,vol. 16, pp. 31- 41 ,(1976) , 10.1159/000180580
David M. Clive, Jeffrey S. Stoff, Renal Syndromes Associated with Nonsteroidal Antiinflammatory Drugs New England Journal of Medicine. ,vol. 310, pp. 563- 572 ,(1984) , 10.1056/NEJM198403013100905