Activation of tyrosine hydroxylation in rat brain in vivo by chlorpromazine.
作者： W. P. BURKARD , K. F. GEY , A. PLETSCHER
DOI: 10.1038/213732A0
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摘要: PHENOTHIAZINES and related neuroleptic drugs, such as thioxanthenes, markedly increase the content of homovanillic acid (3-methoxy-4-hydroxyphenylacetic acid) in brain, especially extrapyramidal centres various animal species. This has raised question whether drugs accelerate synthesis catecholamines through a feed-back mechanism either result blockade dopaminergic noradrenergic receptors or alteration amine storage1–6,16. The present communication shows that vivo chlorpromazine neuroleptics enhance hydroxylation tyrosine which seems to be rate-limiting step formation catecholamines7.
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Louis Shuster, Ruth V. Hannam, THE INDIRECT INHIBITION OF PROTEIN SYNTHESIS IN VIVO BY CHLORPROMAZINE. Journal of Biological Chemistry. ,vol. 239, pp. 3401- 3406 ,(1964) , 10.1016/S0021-9258(18)97736-7
Toshiharu Nagatsu, Morton Levitt, Sidney Udenfriend, TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS. Journal of Biological Chemistry. ,vol. 239, pp. 2910- 2917 ,(1964) , 10.1016/S0021-9258(18)93832-9
H. Bernheimer, O. Hornykiewicz, Wirkung von Phenothiazinderivaten auf den Dopamin-(=3-Hydroxytyramin-)Stoffwechsel im Nucleus caudatus Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 251, pp. 135- 136 ,(1965) , 10.1007/BF00420105
Nils-Erik Andén, Björn-Erik Roos, Bengt Werdinius, Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum☆ Life Sciences. ,vol. 3, pp. 149- 158 ,(1964) , 10.1016/0024-3205(64)90196-1
M. Da Prada, A. Pletscher, Acceleration of the cerebral dopamine turnover by chlorpromazine. Cellular and Molecular Life Sciences. ,vol. 22, pp. 465- 466 ,(1966) , 10.1007/BF01900988
Arthur Yuwiler, Edward Geller, Shawn Schapiro, Grant G. Slater, Adrenocortical and enzymic effects of imipramine and chlorpromazine Biochemical Pharmacology. ,vol. 14, pp. 621- 623 ,(1965) , 10.1016/0006-2952(65)90234-0
Abraham Satanove, Pigmentation Due to Phenothiazines in High and Prolonged Dosage JAMA: The Journal of the American Medical Association. ,vol. 191, pp. 263- 268 ,(1965) , 10.1001/JAMA.1965.03080040005001
Sydney Spector, Albert Sjoerdsma, Morton Levitt, Sidney Udenfriend, ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART Journal of Pharmacology and Experimental Therapeutics. ,vol. 148, pp. 1- 8 ,(1965)
A. Pletscher, K. F. Gey, EFFECTS OF CHLORPROMAZINE ON THE METABOLISM OF dl-2-C14-DOPA IN THE RAT Journal of Pharmacology and Experimental Therapeutics. ,vol. 145, pp. 337- 343 ,(1964)
Udenfriend S, Waalkes Tp, A fluorometric method for the estimation of tyrosine in plasma and tissues. Journal of Laboratory and Clinical Medicine. ,vol. 50, pp. 733- 736 ,(1957) , 10.5555/URI:PII:0022214357901221