Increase of 3-methoxy-4-hydroxyphenylethylene glycol in rat brain by neuroleptic drugs
作者： H.H. Keller , G. Bartholini , A. Pletscher
DOI: 10.1016/0014-2999(73)90054-X
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摘要: Abstract The potency of various neuroleptic drugs in increasing the content endogenous 3-methoxy-4-hydroxyphenyl-ethylene glycol (MOPEG) rat brain decreased order methiothepin, haloperidol, clozapine, thioridazine, chlorpromazine, pimozide. neuroleptics, except pimozide and also caused a slight to moderate diminution cerebral noradrenaline (NA). Based on these earlier findings it is concluded that (a) changes NA turnover induced by neuroleptics can be estimated, relatively simple way, measuring MOPEG; (b) markedly differ their ability activate noradrenergic neurons; (c) activation neurons does not seem parallel dopaminergic neurons.
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