Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
作者： Omiya Yuji , Goto Kazuhiro , Suzuki Yasuyuki , Ishige Atsushi , Komatsu Yasuhiro
DOI: 10.1254/JJP.79.295
关键词:
摘要: Abstract The analgesia-producing mechanism of processed Aconiti tuber was examined using rodents whose nociceptive threshold decreased by loading repeated cold stress (RCS). antinociceptive effect (0.3 g/kg, p.o.) in RCS-loaded mice antagonized pretreatment with a /r-opioid antagonist, nor-binaltorphimine (10 mg/kg, s.c.), and abolished an intrathecal injection anti-dynorphin antiserum (5 μg). tuber-induced antinociception inhibited both dexamethasone (0.4 i.p.) dopamine D2 sulpiride i.p.), mice, it eliminated electric lesion the hypothalamic arcuate nucleus (HARN) highly selective eticlopride (0.05 μg), administered into HARN rats. These results suggest that analgesic produced via stimulation yc-opioid receptors dynorphin released spinal cord. It also shown were involved expression activity tuber.
sci-hub.se 参考文章(17)
Chifuyu Takeshige, Takao Sato, Takashi Mera, Tadashi Hisamitsu, Jianqiao Fang, Descending pain inhibitory system involved in acupuncture analgesia. Brain Research Bulletin. ,vol. 29, pp. 617- 634 ,(1992) , 10.1016/0361-9230(92)90131-G
Mitsuo Murayama, Tomoko Ito, Chohachi Konno, Hiroshi Hikino, Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. European Journal of Pharmacology. ,vol. 101, pp. 29- 36 ,(1984) , 10.1016/0014-2999(84)90027-X
Yasuyuki SUZUKI, Yuki HAYAKAWA, Tsutomu OYAMA, Tomoko ISONO, Yuji OHMIYA, Yoshiki IKEDA, Akitoshi ASAMI, Masamichi NOGUCHI, Analgesic effect of benzoylmesaconine. Folia Pharmacologica Japonica. ,vol. 102, pp. 399- 404 ,(1993) , 10.1254/FPJ.102.399
Yasuyuki Suzuki, Tsutomu Oyama, Atsushi Ishige, Tomoko Isono, Akitoshi Asami, Yoshiki Ikeda, Masamichi Noguchi, Yuji Omiya, Antinociceptive mechanism of the aconitine alkaloids mesaconitine and benzoylmesaconine Planta Medica. ,vol. 60, pp. 391- 394 ,(1994) , 10.1055/S-2006-959516
Masamichi Satoh, Yasushi Kuraishi, Minoru Kawamura, Effects of intrathecal antibodies to substance P, calcitonin gene-related peptide and galanin on repeated cold stress-induced hyperalgesia: comparison with carrageenan-induced hyperalgesia. Pain. ,vol. 49, pp. 273- 278 ,(1992) , 10.1016/0304-3959(92)90151-Z
Tomoko Isono, Tsutomu Oyama, Akitoshi Asami, Yasuyuki Suzuki, Yuki Hayakawa, Yoshiki Ikeda, Masamichi Noguchi, Yuji Omiya, The analgesic mechanism of processed Aconiti tuber: the involvement of descending inhibitory system. The American Journal of Chinese Medicine. ,vol. 22, pp. 83- 94 ,(1994) , 10.1142/S0192415X94000115
R. A. Gross, R. L. Macdonald, Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 5469- 5473 ,(1987) , 10.1073/PNAS.84.15.5469
Janice L.K. Hylden, George L. Wilcox, Intrathecal morphine in mice: A new technique European Journal of Pharmacology. ,vol. 67, pp. 313- 316 ,(1980) , 10.1016/0014-2999(80)90515-4
HIROSHI HIKINO, TOMOKO ITO, CHIZUKO YAMADA, HIROSHI SATO, CHOHACHI KONNO, YASUSHI OHIZUMI, ANALGESIC PRINCIPLES OF ACONITUM ROOTS Journal of pharmacobio-dynamics. ,vol. 2, pp. 78- 83 ,(1979) , 10.1248/BPB1978.2.78
Michael J. Iadarola, Linda S. Brady, Gaetano Draisci, Ronald Dubner, Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor binding. Pain. ,vol. 35, pp. 313- 326 ,(1988) , 10.1016/0304-3959(88)90141-8