Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats.
作者： Hongmeng Xu , Hideko Arita , Masakazu Hayashida , Liang Zhang , Hiroshi Sekiyama
DOI: 10.1016/J.JEP.2005.08.050
关键词: Dose–response relationship 、 Opioid 、 (+)-Naloxone 、 Receptor antagonist 、 Placebo 、 Anesthesia 、 Analgesic 、 κ-opioid receptor 、 Medicine 、 Neuropathic pain 、 Pharmacology
摘要: Neuropathic pain is often refractory to conventional therapies and thus requires exploration of effective drugs. We evaluated if processed Aconiti tuber (PAT), a traditional oriental herbal medicine that has been used as an analgesic, relieves neuropathic in the rat chronic constriction injury (CCI) model. Ten 14 days after CCI right hind paw, six groups rats received oral placebo, or PAT at 0.5, 1, 2, 3, 5 g/kg. Additional PAT, 2 g/kg, pretreatment with intraperitoneal naloxone; nor-binaltorphimine (norBNI); intrathecal norBNI. As indicators mechanical allodynia thermal hyperalgesia, pressure threshold paw withdrawal (PWT) response linearly increasing pressure, latency (PWL) radiant heat, were measured before drug administration. Oral dose-dependently increased PWT PWL, which had decreased due CCI. The increases PWL by inhibited norBNI: selective kappa-opioid receptor antagonist, but not naloxone. These results indicate can alleviate dose-dependently, via spinal mechanisms
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