Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity.
作者： Hajime Hoshino , Hideaki Obata , Shigeru Saito
DOI: 10.1016/J.NEULET.2015.06.041
关键词:
摘要: Antidepressants such as serotonin-noradrenaline reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs) are frequently used for the management of neuropathic pain. Noradrenaline (NA) serotonin (5-HT) increase in spinal cord by inhibition is considered to be main mechanism therapeutic effect In present study, we examined analgesic effects duloxetine (SNRI) amitriptyline (TCA) a rat model pain induced nerve ligation (SNL). Intraperitoneal administration dose-dependently (3,10 30 mg/kg) suppressed hyperalgesia SNL. vivo microdialysis lumbar dorsal horn revealed that NA 5-HT concentrations increased after intraperitoneal (10 mg/kg, respectively). We further determined contents homogenized samples from ipsilateral Although content SNL rats 2 weeks was higher than 4 ligation, efficacy similar between two groups. The study suggests NA/5-HT crucial antihyperalgesic amitriptyline. plastic change descending noradrenergic system does not obviously affect
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