Interleukin-17: A novel inflammatory cytokine that bridges innate and adaptive immunity

摘要: Interleukin-17 (IL-17A) is a pro-inflammatory cytokine that primarily secreted from T lymphocytes, mediators of adaptive immunity. Recently, IL-17 was shown to be the defining new helper subset termed "Th17." Discovery Th17 population groundbreaking discovery has triggered major revisions prevailing paradigms in cell biology. Although produced by cells, promotes expansion and recruitment innate immune cells such as neutrophils, also cooperates with TLR ligands, IL-1 beta, TNF alpha enhance inflammatory reactions stimulate production beta-defensins other antimicrobial peptides. Its receptor, IL-17RA, ubiquitously expressed shares many features classical receptors shared intracellular tail motifs convergence on common transcription pathways. The role periodontal disease still uncertain, since been promote bone destruction arthritis, but nonetheless essential protect host pathogens, including periodontopathic organisms. Recent evidence are more osteoclastogenic than subsets Th1 or Th2. Ablation signaling prior onset infection Porphyromonas gingivalis increases susceptibility loss, this finding does not rule out efficacy therapeutic inhibition after severe disease. sits at center complex diseases integrate mechanisms requires careful study maximize protective effects minimize deleterious effects.