Tryptophan and Nitric Oxide in Allergy
作者： Kathrin Becker , Giorgio Ciprandi , Johanna Gostner , Heinz Kofler , Dietmar Fuchs
DOI: 10.1007/978-3-319-15630-9_3
关键词:
摘要: An immune deviation toward Th2-type immunity is involved in the pathogenesis of allergic asthma and rhinitis. Allergic inflammation characterized by upregulation cytokines (the so-called Th2 polarization), whereas there a downregulation Th1-type response related like interferon-γ (IFN-γ). The latter strong inducer enzyme indoleamine 2,3-dioxygenase (IDO), which degrades essential amino acid tryptophan as part an antiproliferative strategy immunocompetent cells to halt growth infected malignant cells. Tryptophan metabolism may also play relevant role pathophysiology disorders.
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