Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine.
作者： Maki Sonoda , Tadashi Nishiyama , Yoshizumi Matsukawa , Masataka Moriyasu
DOI: 10.1016/J.JEP.2003.11.014
关键词:
摘要: The effects of 17 flavonoids, isolated from two flavonoid-rich Scutellaria species (Scutellaria baicalensis Georgi and Scutellaria rivularis Wall) used in traditional Chinese medicine, on HL-60 cells were assessed by WST-8. Ten of the flavonoids inhibited the proliferation of HL-60, as shown by IC50 values used as indexes of the inhibition. 2′, 3′, 5, 7-tetrahydroxy flavone (IC50= 9.5 μM), apigenin (15.0 μM), viscidulin III (17.4 μM), wogonin (17.4 μM) and luteolin (18.4 μM) were more effective than baicalein (23.0 μM) which reportedly inhibits the …
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