Nerve growth factor released into the bloodstream following intraspecific fighting induces mast cell degranulation in adult male mice

摘要: Nerve growth factor (NGF) is stored in the salivary glands of adult male mice. Recent evidence has shown that NGF active on cell lines immune system. Following isolation-induced fighting (20 min session) released into bloodstream, causing disruption cytoplasmic membranes and concomitant degranulation peritoneal mast cells (MCs). Fluorometric determinations showed an increase histamine levels fluid Administration antibodies or sialoadenectomy prior to session blocks MC degranulation. These results, together with other observations, suggest endogenous plays a physiological role activation.