Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: results from experimental stress and diabetes.
作者： Federica Sornelli , Luigi Aloe , George N Chaldakov , Marco Fiore
DOI:
关键词: Brain-derived neurotrophic factor 、 Neurotrophin 、 Adipose tissue 、 Neurotrophic factors 、 Endocrinology 、 Nerve growth factor 、 Adipokine 、 Brown adipose tissue 、 Paracrine signalling 、 Internal medicine 、 Biology
摘要: Recently, adipobiology (adiposcience) became a focus of numerous studies showing that the adipose tissue is body's largest endocrine and paracrine organ producing multiple signaling proteins collectively designated adipokines; at present these include more than hundred proteins. However, on neurotrophins have recently emerged, nerve growth factor (NGF) brain-derived neurotrophic (BDNF) being examples adipose-derived neurotrophins. Here we data NGF BDNF are expressed in both white brown following experimental stress (in mice) type 1 diabetes rats). We suggest metabotrophic potentials may be involved molecular mechanism consequently, pathogenesis cardiometabolic diseases.
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