miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6.
作者： Chao Lei , Feng Du , Lina Sun , Ting Li , Tingyu Li
关键词:
摘要: Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators metastasis that act by modulating their target genes. In this study, we found miR-143 miR-145 via common gene, MYO6, to regulate epithelial-mesenchymal transition (EMT) inhibit metastasis. We determined were downregulated in GC, ectopic expression and/or inhibited GC cell migration Furthermore, MYO6 was identified as direct elevated GC. Silencing resulted metastasis-suppressive activity similar miR-145, while restoring attenuated anti-metastatic or anti-EMT effects caused miR-145. Clinically, an inverse correlation observed between miR-143/145 levels tissues, either downregulation upregulation associated with more malignant phenotypes patients conclusion, suppress inhibiting EMT, which provides novel mechanism promising therapeutic treatment
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