Effects of a Novel pH-sensitive Liposome With Cleavable Esterase-Catalyzed and pH-responsive Double Smart mPEG Lipid Derivative on ABC Phenomenon
作者： Daquan Chen , Wanhui Liu , Yan Shen , Hongjie Mu , Yanchun Zhang
DOI: 10.2147/IJN.S24344
关键词:
摘要: Background The ABC phenomenon is described as a syndrome of accelerated clearance polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in liver and spleen. Methods To clarify this immune response phenomenon, we evaluated novel modified pH-sensitive liposome cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS). Results mice was brought about by repeated injection conventional PEG-PE accompanied greatly uptake liver. However, slight mPEG-CHEMS only slightly liver, mPEG-Hz-CHEMS did not induce there no increase accumulation. This finding indicates that could lessen or eliminate induced PEGylated liposomes. Conclusion research has shed some light on solution to using PEG-Hz-CHEMS encapsulated nanoparticles.
sci-hub.se 参考文章(23)
Adam Judge, Kevin McClintock, Janet R. Phelps, Ian MacLachlan, Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. Molecular Therapy. ,vol. 13, pp. 328- 337 ,(2006) , 10.1016/J.YMTHE.2005.09.014
D.D. Lasic, F.J. Martin, A. Gabizon, S.K. Huang, D. Papahadjopoulos, Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times Biochimica et Biophysica Acta. ,vol. 1070, pp. 187- 192 ,(1991) , 10.1016/0005-2736(91)90162-2
J. Allen Zhang, Gopal Anyarambhatla, Lan Ma, Sydney Ugwu, Tong Xuan, Tommaso Sardone, Imran Ahmad, Development and characterization of a novel Cremophor EL free liposome-based paclitaxel (LEP-ETU) formulation. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 59, pp. 177- 187 ,(2005) , 10.1016/J.EJPB.2004.06.009
Daquan Chen, Xiaoqun Jiang, Jia Liu, Xiang Jin, Can Zhang, Qineng Ping, In Vivo Evaluation of Novel pH-sensitive mPEG-Hz-Chol Conjugate in Liposomes: Pharmacokinetics, Tissue Distribution, Efficacy Assessment Artificial Cells, Blood Substitutes, and Biotechnology. ,vol. 38, pp. 136- 142 ,(2010) , 10.3109/10731191003685481
Tatsuhiro Ishida, Kazutaka Atobe, XingYu Wang, Hiroshi Kiwada, Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection Journal of Controlled Release. ,vol. 115, pp. 251- 258 ,(2006) , 10.1016/J.JCONREL.2006.08.017
H XU, Y DENG, D CHEN, W HONG, Y LU, X DONG, Esterase-catalyzed dePEGylation of pH-sensitive vesicles modified with cleavable PEG-lipid derivatives Journal of Controlled Release. ,vol. 130, pp. 238- 245 ,(2008) , 10.1016/J.JCONREL.2008.05.009
Tatsuhiro Ishida, Takako Ichikawa, Masako Ichihara, Yasuyuki Sadzuka, Hiroshi Kiwada, Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice. Journal of Controlled Release. ,vol. 95, pp. 403- 412 ,(2004) , 10.1016/J.JCONREL.2003.12.011
Donald M. Maxwell, David E. Lenz, William A. Groff, Andris Kaminskis, Harry L. Froehlich, The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats. Toxicology and Applied Pharmacology. ,vol. 88, pp. 66- 76 ,(1987) , 10.1016/0041-008X(87)90270-5
Anil K Singla, Alka Garg, Deepika Aggarwal, Paclitaxel and its formulations. International Journal of Pharmaceutics. ,vol. 235, pp. 179- 192 ,(2002) , 10.1016/S0378-5173(01)00986-3
Junhwa Shin, Pochi Shum, David H Thompson, Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. Journal of Controlled Release. ,vol. 91, pp. 187- 200 ,(2003) , 10.1016/S0168-3659(03)00232-3