A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery.
作者： Shivani Rai Paliwal , Rishi Paliwal , Suresh P. Vyas
DOI: 10.3109/10717544.2014.882469
关键词:
摘要: The pH-sensitive liposomes have been extensively used as an alternative to conventional in effective intracellular delivery of therapeutics/antigen/DNA/diagnostics various compartments the target cell. Such are destabilized under acidic conditions endocytotic pathway they usually contain lipid components. Therefore, encapsulated content is delivered into bio-environment through destabilization or its fusion with endosomal membrane. therapeutic efficacy enables them biomaterial commercial utility especially cancer treatment. In addition, targeting ligands including antibodies can be anchored on surface specific cell receptors/antigen present tumor cells. These vesicles also widely explored for antigen and serve immunological adjuvant enhance immune response antigens. review deals recent research updates application chemotherapy/diagnostics/antigen/gene etc.
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