The relationship of negative schizophrenia to Parkinsonism

摘要: The positive-negative distinction of schizophrenia has emerged as a valid means clarifying its heterogeneity. Despite evidence that the two symptom classes may reflect different dimensions disease, there is presently no integrated model for understanding pathophysiology these symptoms and their co-occurrence in schizophrenia. We propose negative phenomena be variant Parkinsonism. This view supported by overlap with Parkinsonism terms clinical features, neurochemistry, pharmacology, well neuroradiological neuropathological aspects. As such, manifestation disease basal ganglia constitute core pathology Positive symptoms, conversely, an “accessory” process related to compensatory increase striatal limbic dopamine activity following injury dopaminergic system.In present communication we series studies support associati...