Glycomics: an overview of the complex glycocode.

摘要: Carbohydrates coat most cell types and are closely involved in various biological events. Their structures complex to analyze owing their branched nature, the diversity of secondary modifications monomers, indirect relationship genome. Additionally, range cellular milieu which glycan found is immense. Thus, despite genomics proteomics being highly comprehensible manageable scientists, technologies assess rapidly still infancy. Recently, interest profiling glycome has increased due potential glycans as disease markers. Incidentally, mass spectrometry emerging a powerful technique for glycome. This manuscript focuses on current progress glycomics, including new spectrometry-based high-throughput techniques purification annotation, recent work enhancing microarray methodologies decipher glycome, scope