Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

作者: Veronica De Rosa , Mario Galgani , Antonio Porcellini , Alessandra Colamatteo , Marianna Santopaolo

DOI: 10.1038/NI.3269

关键词:

摘要: … cells tightly depended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-… The Foxp3-E2–related suppressive activity of iT reg cells was altered in human …

参考文章(46)
Thomas Magg, Joachim Mannert, Joachim W. Ellwart, Irene Schmid, Michael H. Albert, Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells. European Journal of Immunology. ,vol. 42, pp. 1627- 1638 ,(2012) , 10.1002/EJI.201141838
Magda Carneiro-Sampaio, Antonio Coutinho, Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency Frontiers in Immunology. ,vol. 6, pp. 185- 185 ,(2015) , 10.3389/FIMMU.2015.00185
Guoyan Cheng, Aixin Yu, Thomas R. Malek, T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells Immunological Reviews. ,vol. 241, pp. 63- 76 ,(2011) , 10.1111/J.1600-065X.2011.01004.X
Maria A. Curotto de Lafaille, Andreia C. Lino, Nino Kutchukhidze, Juan J. Lafaille, CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion Journal of Immunology. ,vol. 173, pp. 7259- 7268 ,(2004) , 10.4049/JIMMUNOL.173.12.7259
Wen Lin, Dipica Haribhai, Lance M Relland, Nga Truong, Marc R Carlson, Calvin B Williams, Talal A Chatila, Regulatory T cell development in the absence of functional Foxp3 Nature Immunology. ,vol. 8, pp. 359- 368 ,(2007) , 10.1038/NI1445
Marc A. Gavin, Jeffrey P. Rasmussen, Jason D. Fontenot, Valeria Vasta, Vincent C. Manganiello, Joseph A. Beavo, Alexander Y. Rudensky, Foxp3-dependent programme of regulatory T-cell differentiation Nature. ,vol. 445, pp. 771- 775 ,(2007) , 10.1038/NATURE05543
Aruna Subramanian, Donald M. Miller, Structural Analysis of α-Enolase: MAPPING THE FUNCTIONAL DOMAINS INVOLVED IN DOWN-REGULATION OF THE c-myc PROTOONCOGENE * Journal of Biological Chemistry. ,vol. 275, pp. 5958- 5965 ,(2000) , 10.1074/JBC.275.8.5958
Thomas R. Malek, Iris Castro, Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity Immunity. ,vol. 33, pp. 153- 165 ,(2010) , 10.1016/J.IMMUNI.2010.08.004
Veronica De Rosa, Claudio Procaccini, Gaetano Calì, Giuseppe Pirozzi, Silvia Fontana, Serafino Zappacosta, Antonio La Cava, Giuseppe Matarese, A Key Role of Leptin in the Control of Regulatory T Cell Proliferation Immunity. ,vol. 26, pp. 241- 255 ,(2007) , 10.1016/J.IMMUNI.2007.01.011
Emma L. Smith, Helene M. Finney, Andrew M. Nesbitt, Fred Ramsdell, Martyn K. Robinson, Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation Immunology. ,vol. 119, pp. 203- 211 ,(2006) , 10.1111/J.1365-2567.2006.02425.X