Resveratrol enhances the efficacy of aminoglycosides against Staphylococcus aureus.

摘要: Development of new antibiotics is costly and time-consuming, therefore increasing the efficacy conventional extremely attractive. For human pathogen, Staphylococcus aureus, inactivation ATP synthase increases its susceptibility to gentamicin (an aminoglycoside) 16-fold. Aminoglycosides are rarely used as monotherapy against S. aureus due risk development resistance toxic effects. This study explored possibility enhancing aminoglycosides other Gram-positive pathogens by inhibiting with resveratrol, a polyphenolic inhibitor that commonly dietary supplement. Co-administration subinhibitory concentrations resveratrol increased activity aminoglycosides, including gentamicin, kanamycin, neomycin, streptomycin tobramycin, up 32-fold while effect was lower (2-4-fold reduction in minimum inhibitory concentration) for (i.e. epidermidis, Enterococcus faecium faecalis). The mechanism which appears be unrelated membrane hyperpolarization disruption integrity, have been associated previously aminoglycoside susceptibility. These results demonstrate inhibition important pathogens, should further target may extend clinical applicability aminoglycosides.