Investigations of RPE Cells of Choriodal Neovascular Membranes from Patients with Age-Related Macula Degeneration

摘要: Age-related macular degeneration (AMD) is the most frequent cause for blindness in older age. The severe complication development of choroidal neovascularisation (CNV). retinal pigment epithelium (RPE) plays an important role induction angiogenesis AMD (Glaser et al., 1985; Young, 1987; Morse 1989; Bird, 1991) by secreting majority angiogenic factors (Kliffen 1997). factor VEGF (vascular endothelial growth factor). CNV membranes contain high amounts and it known that overexpression RPE leads to (Schwesinger 2001). In vitro situ investigations revealed several extracellular stimuli inducing secretion RPE. A major part takes a hypoxia-comparable situation area soft drusen (Eagle, 1984). consequence this, production are secreted neuronal retina (D' Amore, 1994; Shima 1995; Stone Frank 1996; Kliffen 1997; Tanihara stimulated advanced-glycation endproducts (AGE) accumulating membranes, also vitronectin, matrix component (Hammes Hageman 1999). addition, insulin-like factor-1 (IGF-1) tumour necrosis factor-a (TNFa) macrophages which migrate towards during first blood vessels induce cells (Punglia Oh