Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease.

摘要: Background & Aims: The Marsh–Oberhuber classification of duodenojejunal mucosal lesions is currently used for celiac disease. A more simplified classification, which based on 3 villous morphologies (A, non-atrophic; B1, atrophic, villous-crypt ratio 25/100 enterocytes, has recently been proposed. aim the study was to asses interobserver agreement between different pathologists in classifying disease according both and new system. Methods: Sixty patients were selected study: 10 subjects without disease, 13 with normal villi but a pathologic increase intraepithelial lymphocytes >25/100 hyperplastic crypts, 37 atrophy. slides sent 6 pathologists, who blinded each other not given any clinical information. Each pathologist received set biopsy specimens 2 separate occasions had evaluate them grading systems random order. kappa statistic assess pair pathologists. Results: Overall, mean values 0.35 (fair) versus 0.55 (moderate) Conclusions: duodenal pathology gives better compared cumbersome contributes validity diagnosis