Hypo-Phosphorylation of Salivary Peptidome as a Clue to the Molecular Pathogenesis of Autism Spectrum Disorders

摘要: RP-HPLC-ESI-MS profile of naturally occurring salivary peptides subjects with autistic spectrum disorder [ASD; N = 27:12 diagnosis autism, 1 Asperger, 14 pervasive developmental disorders not otherwise specified (PDD-NOS)] was compared to that age-matched controls the goal identifying differences could turn out become hallmarks at least a subgroup ASD individuals. Phosphorylation level four specific phospho-peptides, namely statherin, histatin (both, p < 0.0001) and acidic proline-rich proteins (both entire truncated isoforms) (p 0.005) found significantly lower in patients, hypo-phosphorylation one peptide observed 18 (66%). Developmental scale assessment (Griffith or WISC-R) carried on highlighted normal borderline cognitive development 10 them, all included hypo-phosphorylated group. involves Golgi casein kinase common many organs tissues, CNS included, whose expression seems be synchronized during fetal development. Hypo-phosphorylation suggests potential asynchronies phosphorylation other secretory proteins, which relevant either embryonic early infancy. These results suggest analysis phospho-peptides might help discriminate considerable patients.