Thymoquinone Attenuates Brain Injury via an Anti-oxidative Pathway in a Status Epilepticus Rat Model.
作者： Yi-ye Shao , Bing Li , Yong-mei Huang , Qiong Luo , Yang-mei Xie
关键词:
摘要: Aim Status epilepticus (SE) results in the generation of reactive oxygen species (ROS), which contribute to seizure-induced brain injury. It is well known that oxidative stress plays a pivotal role status (SE). Thymoquinone (TQ) bioactive monomer extracted from black cumin (Nigella sativa) seed oil has anti-inflammatory, anti-cancer, and antioxidant activity various diseases. This study evaluated protective effects TQ on injury lithium-pilocarpine rat model SE investigated underlying mechanism related antioxidative pathway. Methods Electroencephalogram Racine scale were used value seizure severity. Passive-avoidance test was determine learning memory function. Moreover, anti-oxidative observed using Western blot super oxide dismutase (SOD) assay. Results Latency increased TQ-pretreated group compared with rats group, while total power significantly lower. Seizure severity measured lower group. behavioral experiments suggest may also have effect Investigation showed TQ-pretreatment expression Nrf2, HO-1 proteins SOD hippocampus. Conclusion These findings attenuated induced by via an
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