Impact of medication therapy discontinuation on mortality after myocardial infarction.

摘要: Background: Nonadherence to medications is common, but the determinants and consequences are poorly defined. The objectives of this study were identify patient myocardial infarction (MI) treatment factors associated with medication therapy discontinuation assess impact 1 month after MI on 12-month mortality. Methods: This was a multicenter prospective cohort patients enrolled in Prospective Registry Evaluating Myocardial Infarction: Event Recovery study.Theoutcomeswereuseofaspirin,-blockers,and statins at hospitalization among discharged all 3 as well 12month Results: Of 1521 medications,184discontinueduseofall3medications,56discontinued use 2 medications, 272 discontinued medication, 1009 continued taking month. In multivariable analyses, not graduating from high school (odds ratio [OR], 1.76; 95%confidenceinterval[CI],1.20-2.60)weremorelikely discontinue medications. effect increasing age greater for females (OR, 1.77; 95% CI, 1.34-2.34) than males 1.23; 1.02-1.47). Patients who had lower 1-yearsurvival(88.5%vs97.7%;log-rankP.001)comparedwithpatientswhocontinuedtotake1ormoremedication(s). survival analysis, independently higher mortality (hazards ratio, 3.81; 1.887.72). Results consistent when evaluating aspirin, -blockers, separately.